Cutting Edge: Unusual NK Cell Responses to HIV-1 Peptides Are Associated With Protection Against Maternal-Infant Transmission of HIV-1
نویسنده
چکیده
METHODS. CD3 cell responses to HIV-1 peptide were measured in HIV-infected mothers and their infants at birth and at 6 to 10 weeks after delivery. Samples from the mother-child cohort were stimulated with HIV-1 synthetic peptides in pools representing Gag, Pol, Nef, envelope, and regulatory protein regions. A positive peptide-induced CD3 response was defined as 3% of cells expressing cytokine at a level at least twofold above background levels. Additional HIVinfected women were recruited to determine whether CD3 HIV-responding cells expressed markers for B cells, monocytes, T cells, or natural killer (NK) cells.
منابع مشابه
Cutting Edge: Unusual NK Cell Responses to HIV-1 Peptides Are Associated With Protection Against Maternal-Infant Transmission of HIV-1
METHODS. CD3 cell responses to HIV-1 peptide were measured in HIV-infected mothers and their infants at birth and at 6 to 10 weeks after delivery. Samples from the mother-child cohort were stimulated with HIV-1 synthetic peptides in pools representing Gag, Pol, Nef, envelope, and regulatory protein regions. A positive peptide-induced CD3 response was defined as 3% of cells expressing cytokine a...
متن کاملCutting Edge: Unusual NK cell responses to HIV-1 peptides are associated with protection against maternal-infant transmission of HIV-1.
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